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不育夫妇白细胞迁移试验中精液成分的影响。

Effects of seminal constituents in leucocyte migration tests on infertile couples.

作者信息

Mirecka J, Bromboszcz A, Komorowska Z, Bobrzyńska B

出版信息

J Reprod Immunol. 1981 Mar;2(6):331-7. doi: 10.1016/0165-0378(81)90003-6.

DOI:10.1016/0165-0378(81)90003-6
PMID:7012335
Abstract

Leucocyte migration tests were performed with cells from both partners of infertile couples in the presence of seminal constituents from the male partners. Leucocytes from fertile women were used as controls. Homogenized spermatozoa inhibited leucocyte migration in 36.1% of women and 20.7% of men from infertile couples and in 18.4% of control women. In all groups, occasional stimulation of leucocyte migration was observed (8.3%, 3.4% and 2.6% respectively). Although both types of changes in migration when considered together were statistically more frequent in the group of infertile women it was not possible to distinguish, on the basis of this test, between fertile and supposedly infertile individual women. It is suggested, however, that an inhibitory effect induced by spermatozoa on the men's own leucocytes may be of diagnostic significance. In contrast to spermatozoa, seminal plasma caused inhibition of leucocyte migration in the majority of cases -- 88% of women and 71.9% of men from infertile couples and 77.8% of fertile women. Those patients whose semen lacked this inhibitory property are deserving of further study.

摘要

在男性伴侣的精液成分存在的情况下,对不育夫妇双方的细胞进行了白细胞迁移试验。以可育女性的白细胞作为对照。匀浆后的精子抑制了36.1%的不育夫妇女性、20.7%的不育夫妇男性以及18.4%的对照女性的白细胞迁移。在所有组中,偶尔也观察到白细胞迁移受到刺激(分别为8.3%、3.4%和2.6%)。虽然综合考虑这两种迁移变化类型在不育女性组中在统计学上更为常见,但基于此试验无法区分可育和疑似不育的个体女性。然而,有人认为精子对男性自身白细胞的抑制作用可能具有诊断意义。与精子不同,精液浆在大多数情况下会抑制白细胞迁移——不育夫妇中88%的女性和71.9%的男性以及77.8%的可育女性。那些精液缺乏这种抑制特性的患者值得进一步研究。

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