Richard J L
Rev Epidemiol Sante Publique. 1980 Dec 30;28(4):461-87.
A clear association is observed between saturated fats in the diet, mean serum cholesterol and the frequency of coronary heart disease (CHD) among human populations. Such an association led to a pathogenic interpretation: the diet heart hypothesis. But epidemiological studies have not put forward coherent relations between individual consumption of fats and either cholesterolemia or the risk of developing a CHD. No preventive trial has shown any definitely coherent and significant reduction of the incidence of CHD after a decrease of serum cholesterol following diet modifications. However changes of relative proportions of saturated and polyunsaturated fats induce predictable variations of the mean serum cholesterol of a group which can be maintained in free living populations by appropriate diet modifications on long periods of time. Such conflicting data are discussed with reference to methodology, etiological research and public health.
在人群中，饮食中的饱和脂肪、平均血清胆固醇与冠心病（CHD）的发病频率之间存在明显关联。这种关联引发了一种致病学解释：饮食心脏假说。但流行病学研究并未提出个体脂肪摄入量与胆固醇血症或患冠心病风险之间的连贯关系。没有任何预防性试验表明，通过饮食调整降低血清胆固醇后，冠心病发病率有任何明确连贯且显著的降低。然而，饱和脂肪和多不饱和脂肪相对比例的变化会引起一组人群平均血清胆固醇的可预测变化，通过长期适当的饮食调整，这种变化可在自由生活人群中维持。本文将参考方法论、病因学研究和公共卫生对这些相互矛盾的数据进行讨论。
