Welch A
J Biomed Mater Res. 1978 Sep;12(5):679-700. doi: 10.1002/jbm.820120509.
The effect of combining gentamicin and cephalothin with Surgical Simplex bone cement was tested in vitro. Experiments were designed to determine (1) quantitative elution rates and period of time the antibiotics were eluted and (2) effective bactericidal qualities. Both antibiotics were eluted from polymerized acrylic cement in large quantities within 24--48 hr after coming in contact with fluid and continued to be released in smaller amounts for 21 days to more than 175 days. This varied with the antibiotic, concentration of antibiotic in the cement, surface area of cement, and volume of elution fluid. Quantitative determinations of numbers of bacteria in broth cultures demonstrated that sufficient quantities of antibiotics were released to be bactericidal to microorganisms within 45 min to 20 hr. This was dependent on the type of antibiotic, type of bacteria, concentration of antibiotic in the cement, and time of contact.
在体外测试了庆大霉素和头孢噻吩与外科用单纯型骨水泥联合使用的效果。实验旨在确定：（1）抗生素的定量洗脱率和洗脱时间；（2）有效的杀菌质量。两种抗生素在与液体接触后的24至48小时内大量从聚合丙烯酸骨水泥中洗脱出来，并在21天至超过175天的时间内持续少量释放。这随抗生素种类、骨水泥中抗生素浓度、骨水泥表面积和洗脱液体积而变化。肉汤培养物中细菌数量的定量测定表明，在45分钟至20小时内释放出足够量的抗生素对微生物具有杀菌作用。这取决于抗生素类型、细菌类型、骨水泥中抗生素浓度以及接触时间。
