Schurman D J, Trindade C, Hirshman H P, Moser K, Kajiyama G, Stevens P
J Bone Joint Surg Am. 1978 Oct;60(7):978-84.
Palacos bone cement with and without contained gentamicin was tested for antibacterial efficacy using a rabbit model of a knee hemiarthroplasty and a challenge with intra-articular Escherichia coli. The gentamicin-containing cement prevented infection from challenge with Escherichia coli and protected against inadvertent operative infection as well. Antibiotic concentrations in synovial fluid and urine remained in the therapeutic range for three days, whereas levels in serum were always quite low. Eight per cent of the gentamicin had leached out of the bone cement by eight days, most of it during the first day. Thereafter, extremely small amounts of gentamicin left the cement on a daily basis. The amount of antibiotic leaching out in vitro was proportional to the surface area of the cement. More eluted into serum than into saline.
使用兔膝关节半关节置换模型并通过关节内注射大肠杆菌进行挑战，对含和不含庆大霉素的Palacos骨水泥的抗菌效果进行了测试。含庆大霉素的骨水泥可预防大肠杆菌攻击引起的感染，也能防止意外手术感染。滑液和尿液中的抗生素浓度在三天内保持在治疗范围内，而血清中的浓度一直很低。到第八天，8%的庆大霉素已从骨水泥中渗出，大部分是在第一天。此后，每天从骨水泥中渗出的庆大霉素量极少。体外渗出的抗生素量与骨水泥的表面积成正比。渗入血清的量比渗入盐水的量多。
