Welch A B
J Biomed Mater Res. 1978 Nov;12(6):843-55. doi: 10.1002/jbm.820120607.
In vivo experiments were performed to study elution rates of antibiotics combined with Surgical implex bone cement and efficacy in controlling bacterial infections. Cylinders of bone cement were implanted in animals and at the same time the surgical areas were infected with large numbers of bacteria. Gentamicin and Keflin were eluted from the cylinders in sufficient quantities to completely eliminate or markedly reduce the number of bacteria recovered from infected areas. Animals were also treated with an anti-inflammatory drug, hydrocortisone, prior to implantation of cylinders and infection. The antibiotics in the bone cement effectively destroyed the bacteria in these animals with impaired inflammatory responses as compared with control animals.
进行体内实验以研究抗生素与外科用骨水泥结合后的洗脱率及其控制细菌感染的效果。将骨水泥圆柱体植入动物体内，同时使手术区域感染大量细菌。庆大霉素和头孢菌素从圆柱体中充分洗脱，足以完全消除或显著减少从感染区域回收的细菌数量。在植入圆柱体和感染之前，还对动物使用了一种抗炎药物氢化可的松进行治疗。与对照动物相比，骨水泥中的抗生素有效破坏了这些炎症反应受损动物体内的细菌。
