Pritchard L L, Halle-Pannenko O
Transplantation. 1981 Apr;31(4):257-61. doi: 10.1097/00007890-198104000-00005.
The greater severity of the graft-versus-host (GVH) reaction induced by grafting C57BL/6(B6) lymphoid or bone marrow cells to irradiated (B6 x DBA/2)F1 recipients, as compared to that induced in H-2-identical (B6 x BALB/c)F1 recipients, has been shown to arise from a synergistic effect of H-2d and DBA/2 minor histocompatibility antigens (MiHAs), and not from a difference in the intensity of genetic resistance to B6 cell grafts exhibited by the two F1s. Furthermore, detection of such synergistic effects depends upon choice of an appropriate assay system; GVH splenomegaly results cannot be used to predict the outcome of a systemic GVH reaction.
与将C57BL/6（B6）淋巴细胞或骨髓细胞移植到经照射的（B6×DBA/2）F1受体所诱导的移植物抗宿主（GVH）反应相比，将其移植到H-2相同的（B6×BALB/c）F1受体所诱导的GVH反应更严重，这已表明是由H-2d和DBA/2次要组织相容性抗原（MiHAs）的协同作用引起的，而不是由这两种F1对B6细胞移植的遗传抗性强度差异所致。此外，这种协同效应的检测取决于合适检测系统的选择；GVH脾肿大结果不能用于预测全身性GVH反应的结果。
