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大鼠母体乙醇摄入与胎儿发育:乙醇暴露技术的比较

Maternal ethanol consumption and fetal development in the rat: a comparison of ethanol exposure techniques.

作者信息

Samson H H

出版信息

Alcohol Clin Exp Res. 1981 Jan;5(1):67-74. doi: 10.1111/j.1530-0277.1981.tb04867.x.

DOI:10.1111/j.1530-0277.1981.tb04867.x
PMID:7013550
Abstract

Comparison of the polydipsia and liquid diet procedures for ethanol exposure were used in female rats, either before and/or during gestation. Autopsy of the fetuses on day 20 of gestation found a significant weight reduction in the polydipsia-exposed animals that could be attributed to ethanol. No such effect was found in the liquid diet-exposed animals. The data are discussed in relation to the human fetal alcohol syndrome.

摘要

在雌性大鼠妊娠前和/或妊娠期间,采用多饮法和液体饮食法进行乙醇暴露比较。在妊娠第20天对胎儿进行尸检发现,多饮法暴露组动物的体重显著减轻,这可能归因于乙醇。而在液体饮食法暴露组动物中未发现此效应。这些数据结合人类胎儿酒精综合征进行了讨论。

相似文献

1
Maternal ethanol consumption and fetal development in the rat: a comparison of ethanol exposure techniques.大鼠母体乙醇摄入与胎儿发育:乙醇暴露技术的比较
Alcohol Clin Exp Res. 1981 Jan;5(1):67-74. doi: 10.1111/j.1530-0277.1981.tb04867.x.
2
Early fetal growth and development in mice chronically exposed to ethanol during gestation.孕期长期暴露于乙醇环境下的小鼠的早期胎儿生长与发育
Growth. 1987 Spring;51(1):146-53.
3
Ethanol-induced prenatal growth deficiency: changes in fetal body composition.乙醇诱导的产前生长缺陷:胎儿身体成分的变化。
J Pharmacol Exp Ther. 1979 Dec;211(3):668-71.
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Effect of prenatal ethanol exposure on fetal calcium metabolism.产前乙醇暴露对胎儿钙代谢的影响。
Alcohol Clin Exp Res. 1997 Dec;21(9):1612-8.
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Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice.小鼠孕期过度暴露于母体糖皮质激素导致乙醇诱导的胎儿下丘脑-垂体-肾上腺轴抑制。
Exp Toxicol Pathol. 2011 Nov;63(7-8):607-11. doi: 10.1016/j.etp.2010.04.015. Epub 2010 Jun 7.
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Effect of duration of maternal alcohol consumption on calcium metabolism and bone in the fetal rat.母鼠酒精摄入持续时间对胎鼠钙代谢和骨骼的影响。
Alcohol Clin Exp Res. 2004 Mar;28(3):456-67. doi: 10.1097/01.alc.0000118312.38204.c5.
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The role of maternal diet in the developmental toxicology of ethanol.母体饮食在乙醇发育毒理学中的作用。
Toxicol Appl Pharmacol. 1984 Apr;73(2):256-67. doi: 10.1016/0041-008x(84)90331-4.
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Effect of prenatal exposure to ethanol on development of the thymus.产前暴露于乙醇对胸腺发育的影响。
Thymus. 1987;9(4):211-5.
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[Effects of ethanol exposure beginning at an early age on maternal rat and their offspring].早年开始接触乙醇对母鼠及其后代的影响
Arukoru Kenkyuto Yakubutsu Ison. 1991 Dec;26(6):544-68.
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Growth of fetuses of rats exposed to ethanol and cigarette smoke during gestation.
Growth Dev Aging. 1989 Autumn;53(3):129-34.

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Public Health Rep. 1988 Nov-Dec;103(6):699-707.