食物链中沙门氏菌的抗生素耐药性与R质粒：质粒相关性证据
Antibiotic resistance and R-plasmids in food chain Salmonella: evidence of plasmid relatedness.
作者信息
Bezanson G S, Pauzé M, Lior H
出版信息
Appl Environ Microbiol. 1981 Mar;41(3):585-92. doi: 10.1128/aem.41.3.585-592.1981.
A large number of strains (1,783) belonging to 15 Salmonella serovars isolated, in Canada, from the three major links of the human food chain were screened for multiple antibiotic resistance and the presence of R-plasmids. Multiresistant strains occurred among animal feed, livestock, and human isolates at frequencies of 4, 22, and 14%, respectively. Conjugation analysis revealed that 58% of the isolates from feeds, 87% of those from livestock, and 89% of the human strains carried all or part of their resistance determinants extrachromosomally on R-plasmids. Conjugative plasmids representing nine different incompatibility groups were detected, with the Inc I alpha group being predominant. Within the limits of the parameters measured, certain of these plasmids show a degree of relatedness suggestive of a common ancestry.
从加拿大人类食物链的三个主要环节分离出属于15种沙门氏菌血清型的大量菌株（1783株），对其进行多重抗生素抗性和R质粒存在情况的筛选。动物饲料、家畜和人类分离株中的多重耐药菌株出现频率分别为4%、22%和14%。接合分析表明，饲料分离株中有58%、家畜分离株中有87%、人类菌株中有89%的抗性决定因素全部或部分位于R质粒的染色体外。检测到代表9个不同不相容群的接合质粒，其中Inc I alpha群占主导。在所测参数范围内，其中一些质粒显示出一定程度的相关性，表明有共同的祖先。
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