Archer L T, White G L, Beller-Todd B, Elmore O F, Glasgow J S, Hinshaw L B
Circ Shock. 1980;7(4):425-33.
Recent reports have suggested that anesthesia may weaken host defense mechanisms during shock and depress the activities of circulating leukocytes. The purpose of this study was to assay the effects of sodium pentobarbital anesthesia on glucose uptake and survival of leukocytes, and mortality of E coli organisms in vitro. In vitro experiments were performed on canine blood before and after the in vivo administration of anesthesia and the in vitro addition of E coli. Glucose uptake in vitro increased equally in blood obtained from either awake or anesthetized dogs following incubation with organisms. Live organism concentrations were similarly reduced before and after anesthesia during a two hour in vitro incubation period. Total neutrophil numbers fell equally after two hours of incubation with or without anesthesia, due to the presence of E coli. These data support the view that a surgical level of anesthesia is not deleterious to circulating phagocytes during E coli-induced shock.
最近的报告表明，麻醉可能会在休克期间削弱宿主防御机制，并抑制循环白细胞的活性。本研究的目的是测定戊巴比妥钠麻醉对白细胞葡萄糖摄取和存活以及体外大肠杆菌存活率的影响。在体内给予麻醉前后以及体外添加大肠杆菌后，对犬类血液进行体外实验。与细菌孵育后，从清醒或麻醉犬获得的血液中体外葡萄糖摄取均同等增加。在两小时的体外孵育期内，麻醉前后活细菌浓度同样降低。由于存在大肠杆菌，无论有无麻醉，孵育两小时后总中性粒细胞数量均同等下降。这些数据支持这样一种观点，即在大肠杆菌诱导的休克期间，手术水平的麻醉对循环吞噬细胞无害。
