Archer L T, Beller-Todd B, Elmore O, White G L, Hinshaw L B
Circ Shock. 1981;8(1):59-67.
Recent reports have indicated that circulating leukocytes play a prominent role in promoting survival in endotoxin and live E coli shock. Anesthesia has been reported to compromise host defense by depressing phagocytic activity. This study was designed to determine whether sodium pentobarbital would adversely affect leukocyte concentrations, E coli clearance, blood glucose concentrations, and survival of dogs in lethal E coli shock. A leukocytosis was produced in some dogs using daily sublethal intravenous injections of E coli endotoxin for 3 days. Three groups of dogs were challenged with LD100 E coli: Group A (saline-pretreated, normal leukocyte count, unanesthetized); Group B (endotoxin-pretreated, leukocytotic, anesthetized); and Group C (endotoxin-pretreated, leukocytotic, unanesthetized). Groups B and C reduced circulating E coli concentrations similarly but significantly more than Group A. All animals in Group A died, all in Group C lived, and 67% in Group B lived. The reduction in survival in Group B was probably due to the marked hemoconcentration in the anesthetized dogs which were unable to drink, rather than a compromise of their host defense. Inasmuch as phagocytic activity was similar between anesthetized and unanesthetized dogs, results suggest that barbiturate anesthesia is not deleterious to host defense.
最近的报告表明，循环白细胞在促进内毒素和活大肠杆菌休克的存活中起重要作用。据报道，麻醉会通过抑制吞噬活性来损害宿主防御。本研究旨在确定戊巴比妥钠是否会对致死性大肠杆菌休克犬的白细胞浓度、大肠杆菌清除率、血糖浓度和存活率产生不利影响。一些犬通过连续3天每日静脉注射亚致死剂量的大肠杆菌内毒素产生白细胞增多。三组犬接受LD100大肠杆菌攻击：A组（生理盐水预处理，白细胞计数正常，未麻醉）；B组（内毒素预处理，白细胞增多，麻醉）；C组（内毒素预处理，白细胞增多，未麻醉）。B组和C组降低循环大肠杆菌浓度的情况相似，但显著多于A组。A组所有动物死亡，C组所有动物存活，B组67%存活。B组存活率降低可能是由于无法饮水的麻醉犬出现明显的血液浓缩，而不是其宿主防御受损。由于麻醉犬和未麻醉犬的吞噬活性相似，结果表明巴比妥类麻醉对宿主防御无害。
