Clinical efficacy trial: theophylline vs (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione.

The authors give a synopsis of the results of a clinical efficacy trial involving a comparison of a new synthetic xanthine derivative (CK 0383) and theophylline, with emphasis on the prevention of exercise-induced asthma (EIA) by both theophylline and the new drug. Although the results are quite preliminary, being based on only five cases, the authors are continuing this study due to findings that show CK 0383 has a good bronchodilating activity without any important side effects.