Acar J F, Goldstein F W, Lagrange P
J Clin Microbiol. 1978 Aug;8(2):142-7. doi: 10.1128/jcm.8.2.142-147.1978.
Stable dwarf forms of Staphylococcus aureus have been identified in clinical specimens as the sole or predominant isolate in eight cases. These organisms have been shown to be menadione or thiamine dependent, i.e., cultivation in the presence of one of these agents has permitted growth of colonies which appear typical of S. aureus. In vitro resistance to aminoglycosides was overcome by cultivation in the presence of menadione or thiamine. Menadione- or thiamine-requiring S. aureus can be considered as causative agents in severe human infections. Special care must be taken if they are to be identified in pathological specimens. Their antibiotic sensitivity testing should be done comparatively on supplemented and nonsupplemented media.
在临床标本中已鉴定出稳定的金黄色葡萄球菌侏儒型，在8例病例中为唯一或主要分离株。这些菌株已被证明依赖甲萘醌或硫胺素，即，在其中一种试剂存在的情况下培养可使菌落生长，这些菌落看起来是典型的金黄色葡萄球菌。在甲萘醌或硫胺素存在的情况下培养可克服体外对氨基糖苷类的耐药性。需要甲萘醌或硫胺素的金黄色葡萄球菌可被视为严重人类感染的病原体。如果要在病理标本中鉴定它们，必须格外小心。它们的抗生素敏感性测试应在补充培养基和非补充培养基上进行比较。
