Devlin R G, Fleiss P M
J Clin Pharmacol. 1981 Feb-Mar;21(2):110-3. doi: 10.1002/j.1552-4604.1981.tb01759.x.
Blood and milk concentrations of captopril, a new antihypertensive agent, were studied in 12 lactating normotensive subjects after the administration of 100 mg captopril tablets on a three times daily regimen for a total of seven doses. Peak blood concentrations (+/- S.E.M.) of captopril after the administration of the seventh 100-mg tablet averaged 713.1 +/- 140.6 ng/ml, as compared to average peak milk concentrations of 4.7 +/- 0.7 ng/ml. Time to peak blood concentrations averaged 1.1 +/- 0.2 hour, while time to peak milk concentrations averaged 3.8 +/- 0.6 hours. The data suggest that the human breast selectively restricts the passage of captopril from blood into milk.
在12名血压正常的哺乳期妇女中进行了研究，她们每日三次服用100毫克卡托普利片，共服用七剂，以观察新型抗高血压药物卡托普利在血液和乳汁中的浓度。服用第七剂100毫克片剂后，卡托普利的血药峰浓度（±标准误）平均为713.1±140.6纳克/毫升，而乳汁中的平均峰浓度为4.7±0.7纳克/毫升。血药峰浓度出现的平均时间为1.1±0.2小时，而乳汁峰浓度出现的平均时间为3.8±0.6小时。数据表明，人体乳腺可选择性地限制卡托普利从血液进入乳汁。
