Husz S, Krizsa F, Dobozy A, Hunyadi J, Simon N
Acta Haematol. 1977;57(6):321-30. doi: 10.1159/000207898.
Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.
针对副蛋白血症患者的骨髓和外周血中的B细胞和T细胞进行了研究。多发性骨髓瘤患者的外周血显示B细胞显著增加，主要是携带与副蛋白相对应的免疫球蛋白的淋巴细胞，而在良性单克隆丙种球蛋白病患者中，仅发现B细胞略有增加，T细胞中度减少。至于骨髓，多发性骨髓瘤患者的B细胞群体显著升高，但在良性单克隆丙种球蛋白病患者中保持不变。我们的发现可能为区分这两种疾病提供新的可能性，并为它们的发病机制提供进一步的数据。
