Wagoner M D, Dohlman C H, Albert D M, Lavin P, Murphy A, O'Neill-Dryja M
Ophthalmology. 1981 Feb;88(2):139-45. doi: 10.1016/s0161-6420(81)35070-2.
The authors conducted the first long-range study to demonstrate possible negative effects on the recipients of corneal transplantation from donors who had died of a systemic malignancy or of chronic neurologic disease. The results are reported of a long-term retrospective analysis of 73 patients who received 86 grafts from donors with various systemic malignancies. These patients were followed for a mean of 127 months. There was no evidence of the transfer of the same malignancy to any of the recipients. There was no increased incidence of malignancy or earlier mortality in our patient population when compared with a reference population. Graft infection, endophthalmitis, or local tumor growth was not observed. The authors state that at the present time there is no basis for excluding donors dying of systemic malignancy as a source of material for use in keratoplasty. The authors examined the case histories of six patients who received grafts from donors who had died of a neurological disease with a suspected viral etiology. In a follow-up period ranging from 120 to 174 months, no evidence of neurologic disease developed in any of the patients. The sample was too small to provide data necessary for drawing conclusions concerning the safety of the use of material from this source. The authors strongly advise excluding any patient with a neurologic disease of suspected viral etiology as a source of corneal donor material.
作者进行了首次长期研究，以证明死于全身性恶性肿瘤或慢性神经疾病的供体进行角膜移植对受体可能产生的负面影响。报告了对73例接受来自患有各种全身性恶性肿瘤供体的86次移植手术患者的长期回顾性分析结果。这些患者平均随访127个月。没有证据表明相同的恶性肿瘤转移到任何受体。与参考人群相比，我们的患者群体中恶性肿瘤发病率没有增加，也没有更早死亡。未观察到移植感染、眼内炎或局部肿瘤生长。作者指出，目前没有理由排除死于全身性恶性肿瘤的供体作为角膜移植材料来源。作者检查了6例接受来自死于疑似病毒病因神经疾病供体移植患者的病历。在120至174个月的随访期内，任何患者均未出现神经疾病迹象。样本量太小，无法提供得出关于使用该来源材料安全性结论所需的数据。作者强烈建议排除任何患有疑似病毒病因神经疾病的患者作为角膜供体材料来源。
