来自摘除的对侧眼球的自体角膜移植治疗脉络膜黑色素瘤：一例报告

Autologous Corneal Transplant from an Enucleated Fellow Eye for Choroidal Melanoma: A Case Report.

作者信息

Iglicki Matias, Loewenstein Anat, Manera Manuel, Castro Claudia, Busch Catharina, Zur Dinah, Negri Hermino Pablo

机构信息

Private Retina Office, University of Buenos Aires, Buenos Aires, Argentina.

Ophthalmology Division, Tel Aviv Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Case Rep Ophthalmol. 2020 May 14;11(2):181-188. doi: 10.1159/000507776. eCollection 2020 May-Aug.

DOI:10.1159/000507776

PMID:32518554

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7265731/

Abstract

BACKGROUND

To report a case of autologous corneal transplant in a patient with corneal leukoma and choroidal melanoma in the fellow eye.

CASE PRESENTATION

A 56-year-old woman was complaining about decrease in vision in her left eye. The patient was on the waiting list for a corneal transplant on her right eye due to corneal leucoma after a previous herpes infection. The patient was diagnosed with choroidal melanoma in her left eye. Due to the tumor size (longitudinal diameter >10 mm; anterior-posterior diameter >16 mm) the patient decided to undergo enucleation, after being informed about different treatment options (brachytherapy and enucleation). The patient showed her willingness to use the cornea of the left eye as a transplant for her right eye. After discussion with the ethical committee and its approval, and signing informed consent, the patient underwent enucleation of her left eye. The sample was examined by a pathologist and found to be free of melanoma cells in the corneolimbal tissue. Afterwards, trepanation of the donor cornea button was performed and transplanted to the left eye.

CONCLUSION

Autologous corneal transplantation is a safe and feasible procedure in selected cases.

摘要

背景

报告一例在对侧眼患有角膜白斑和脉络膜黑色素瘤的患者进行自体角膜移植的病例。

病例介绍

一名56岁女性主诉左眼视力下降。该患者因既往疱疹感染后角膜白斑，右眼正在等待角膜移植。患者左眼被诊断为脉络膜黑色素瘤。鉴于肿瘤大小（纵向直径>10mm；前后直径>16mm），在被告知不同治疗方案（近距离放疗和眼球摘除术）后，患者决定接受眼球摘除术。患者表示愿意将左眼的角膜用于右眼移植。在与伦理委员会讨论并获得批准，签署知情同意书后，患者接受了左眼眼球摘除术。样本经病理学家检查，发现角膜缘组织中无黑色素瘤细胞。随后，对供体角膜植片进行环钻并移植到右眼。