自身免疫性甲状腺疾病中的抗体诱导淋巴细胞细胞毒性（ADCC）和淋巴细胞介导的细胞毒性

Antibody inducing lymphocyte cytotoxicity (ADCC) and lymphocyte-mediated cytotoxicity in auto-immune thyroid diseases.

作者信息

Dessaint J P, Wattre P, Wemeau J L, Capron A, Linquette M

出版信息

Pathol Biol (Paris). 1981 Apr;29(4):211-5.

Abstract

Addition of heat-inactivated serum from patients with autoimmune thyroid diseases to normal nonadherent human lymphoid cells caused significant lysis of thyroglobulin or crude thyroid extract-coated erythrocytes. Serum from 9/10 patients with Hashimoto's thyroiditis induced significant chromium release by normal lymphocytes at higher dilution (greater than 1 : 1 000) than in other thyroid diseases, the mean highest positive dilution being 1 : 535 in Grave's disease and approximately 1 : 200 in primary hypothyroidism, hyperthyroidism without exophthalmos and non toxic goitres. Lymphocyte-mediated cytotoxicity in the absence of serum was found positive on one half of the patients with lymphocyte-dependent antibody. Besides an appraisal of autoimmunization in thyroid diseases, such cell-mediated reactions may indicate how the gland is damaged in autoimmune thyroid diseases.

摘要

将自身免疫性甲状腺疾病患者的热灭活血清添加到正常非贴壁人淋巴细胞中，可导致甲状腺球蛋白或粗甲状腺提取物包被的红细胞发生显著裂解。9/10例桥本甲状腺炎患者的血清在比其他甲状腺疾病更高的稀释度（大于1:1000）下可诱导正常淋巴细胞显著释放铬，在格雷夫斯病中平均最高阳性稀释度为1:535，在原发性甲状腺功能减退症、无突眼性甲状腺功能亢进症和非毒性甲状腺肿中约为1:200。在没有血清的情况下，淋巴细胞介导的细胞毒性在一半伴有淋巴细胞依赖性抗体的患者中呈阳性。除了评估甲状腺疾病中的自身免疫外，这种细胞介导的反应可能表明自身免疫性甲状腺疾病中甲状腺是如何受损的。