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被动梅毒螺旋体血细胞凝集试验(TPHA)在早期梅毒检测中的局限性(作者译)

[Limitations of passive treponema haemagglutination test (TPHA) in the detection of early syphilis (author's transl)].

作者信息

Lefevre J C, Prére M F, Lareng M B

出版信息

Nouv Presse Med. 1981 May 9;10(21):1703-5.

PMID:7015274
Abstract

The sera from 80 patients with clinical signs of primary syphilis were subjected to fluorescent treponemal antibody absorption test (FTA-abs), TPHA test and cardiolipin reactions (Kline, VDRL, Kolmer). The superiority of the FTA-abs test in screening for early primary syphilis was confirmed, but the TPHA test was less sensitive: the sera of 14 patients were reactive in the FTA-abs test and cardiolipins reactions but not in the TPHA test. The TPHA test alone cannot be relied upon to detect early syphilis; when the FTA-abs test is not performed, it must always be combined with one of the cardiolipin reactions.

摘要

对80例有一期梅毒临床症状的患者血清进行梅毒螺旋体荧光抗体吸收试验(FTA - abs)、梅毒螺旋体血凝试验(TPHA)及心磷脂反应(克莱恩试验、性病研究实验室试验、康氏试验)。FTA - abs试验在早期一期梅毒筛查中的优势得到了证实,但TPHA试验敏感性较低:14例患者的血清在FTA - abs试验和心磷脂反应中呈阳性,但在TPHA试验中呈阴性。不能仅依靠TPHA试验来检测早期梅毒;若未进行FTA - abs试验,则必须始终将其与一种心磷脂反应联合使用。

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