Goldfinger D, Lowe C
Transfusion. 1981 May-Jun;21(3):277-80. doi: 10.1046/j.1537-2995.1981.21381201797.x.
We prospectively compared the incidence of complications following saline-washed versus packed red blood cell transfusions, to determine whether routine use of washed red blood cells could reduce significantly the incidence of transfusion reactions. Clinical reports of reactions were evaluated carefully to confirm whether the reaction was caused by transfusion. In 3,799 washed red blood cell transfusions, there were eight confirmed reactions (0.21%). Of 6,359 packed red blood cell transfusions, 31 reactions occurred (0.49%). The difference in incidence of confirmed complications was statistically significant (p less than 0.03). Administration of washed red blood cells to all patients requiring transfusions can thus be seen to reduce significantly the incidence of adverse reactions. This is likely the result of the removal of leukocytes and plasma achieved by the washing process. The increased safety of washed red blood cells must be weighed against their extra expense to determine their cost-effectiveness in transfusion therapy.
我们前瞻性地比较了生理盐水洗涤红细胞与浓缩红细胞输血后并发症的发生率，以确定常规使用洗涤红细胞是否能显著降低输血反应的发生率。仔细评估反应的临床报告，以确认反应是否由输血引起。在3799例洗涤红细胞输血中，有8例确诊反应（0.21%）。在6359例浓缩红细胞输血中，发生了31例反应（0.49%）。确诊并发症发生率的差异具有统计学意义（p小于0.03）。因此，可以看出，对所有需要输血的患者使用洗涤红细胞可显著降低不良反应的发生率。这可能是洗涤过程中去除白细胞和血浆的结果。洗涤红细胞安全性的提高必须与其额外费用相权衡，以确定其在输血治疗中的成本效益。
