[咪唑甲酰胺与亚硝基甲基脲、长春新碱和放线菌素联合用药治疗播散性黑色素瘤的疗效比较]
[Comparison of the efficacy of imidazole-carboxamide and of a combination of nitrosomethylurea, vincristine and dactinomycin in disseminated melanoma].
作者信息
Kogoniia L M, Moroz L V, Perevodchikova N I, Platinskiĭ L V, Borisov A I
出版信息
Vopr Onkol. 1981;27(4):16-21.
A randomized cooperative study comparing 2 regimens of chemotherapy (DTIC--150mg/m2 iv days 1, 2, 3, 4, 5 and a combination of vincristine--1.4 mg/m2 iv days 1, 8, 15, nitrosomethylurea--200 mg/m2 iv days 3, 5, 10, 12 and dactinomycin--0.3 mg/m2 iv days 1, 3, 5, 8, 10, 12) was carried out in 114 patients with disseminated skin melanoma. A combined chemotherapy course given to 58 patients was followed by complete response (CR) in 8 cases (13.7%) and partial response by over 50% (PR)--in 6 cases (10.4%). In 56 patients treated with DTIC, CR was registered in 4 patients (7.1%) and PR in 9 (16%). Patients resistant to one regimen did not respond to the other.
一项随机对照研究比较了两种化疗方案（达卡巴嗪——150mg/m²静脉注射，第1、2、3、4、5天；长春新碱——1.4mg/m²静脉注射，第1、8、15天，亚硝基脲——200mg/m²静脉注射，第3、5、10、12天，放线菌素D——0.3mg/m²静脉注射，第1、3、5、8、10、12天），该研究纳入了114例播散性皮肤黑色素瘤患者。58例接受联合化疗方案的患者中，8例（13.7%）完全缓解（CR），6例（10.4%）部分缓解（PR）超过50%。56例接受达卡巴嗪治疗的患者中，4例（7.1%）完全缓解，9例（16%）部分缓解。对一种方案耐药的患者对另一种方案无反应。
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