一项针对类风湿关节炎患者的肾脏活检的光镜和免疫荧光显微镜研究。
A renal biopsy study with light and immunofluorescent microscopy in rheumatoid arthritis.
作者信息
Orjavik O, Brodwall E K, Oystese B, Natvig J B, Mellbye O J
出版信息
Acta Med Scand Suppl. 1981;645:9-14.
PMID:7015800
Abstract
REnal biopsies were performed on 14 patients with active rheumatoid arthritis an proteinuria of whom 7 patients had reduced creatinine clearance. Glomerular hypercellularity was found in six and amyloid in seven biopsies. Immunofluorescence microscopy revealed glomerula deposits of immunoglobulins and complement in 10 of 12 biopsies, indicating an active immunologic process causing the impaired renal function.
摘要
对14例患有活动性类风湿关节炎且有蛋白尿的患者进行了肾活检，其中7例患者肌酐清除率降低。在6例活检中发现肾小球细胞增多，7例活检中发现淀粉样变。免疫荧光显微镜检查显示，12例活检中有10例肾小球存在免疫球蛋白和补体沉积，表明存在导致肾功能受损的活跃免疫过程。
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