Lau P, Sholtis C M, Aster R H
Am J Hematol. 1980;9(3):331-6. doi: 10.1002/ajh.2830090312.
A patient with post-transfusion purpura is reported. This female patient, sensitized by previous blood transfusion, developed symptomatic thrombocytopenia seven days after a second blood transfusion. A platelet antibody, which had anti-P1A1 specificity, was identified by 51Cr-release assay and by indirect immunofluorescence. Hemorrhage stopped abruptly after plasma exchange therapy. Thrombocytopenia did not recur when the patient was further challenged with P1A1-positive blood and plasma. Anti-P1A1 antibody, detectable by immunofluorescence but not by complement-dependent platelet cytoxicity, persisted in high titer for at least one year after recovery. The heterogeneity and pathogenesis of this clinical syndrome are discussed.
报告了一例输血后紫癜患者。该女性患者因既往输血致敏，在第二次输血后7天出现有症状的血小板减少。通过51Cr释放试验和间接免疫荧光法鉴定出一种具有抗P1A1特异性的血小板抗体。血浆置换治疗后出血迅速停止。当患者再次接受P1A1阳性血液和血浆挑战时，血小板减少未复发。通过免疫荧光可检测到的抗P1A1抗体，而补体依赖性血小板细胞毒性检测不到，在恢复后至少一年内持续高滴度存在。讨论了该临床综合征的异质性和发病机制。
