Yukimura Y, Bray G A, Wolfsen A R
Endocrinology. 1978 Nov;103(5):1924-8. doi: 10.1210/endo-103-5-1924.
Function of the pituitary-adrenal axis was examined in lean and genetically obese fatty (Zucker) rats. The diurnal rhythms of plasma corticosterone and plasma ACTH were similar in both groups. The secretion of corticosterone by adrenal glands incubated in vitro with graded doses of ACTH was also comparable in lean and fatty rats. Adrenalectomy reduced food intake and weight gain in the fatty rats to levels similar to those in the lean animals and raised plasma ACTH to the same level. The injection of corticosterone (2 and 10 mg/day) increased food intake more in adrenalectomized fatty rats than in the corresponding lean ones. Progesterone increased food intake similarly in both groups. The enhanced responsiveness to corticosterone could account for many of the metabolical defects in the fatty rat.
对瘦型和遗传性肥胖型（ Zucker ）大鼠的垂体 - 肾上腺轴功能进行了研究。两组大鼠血浆皮质酮和血浆促肾上腺皮质激素（ACTH）的昼夜节律相似。在体外与不同剂量ACTH一起孵育的肾上腺皮质酮分泌，在瘦型和肥胖型大鼠中也相当。肾上腺切除术使肥胖型大鼠的食物摄入量和体重增加降低到与瘦型动物相似的水平，并使血浆ACTH升高到相同水平。注射皮质酮（2和10毫克/天）在肾上腺切除的肥胖型大鼠中比在相应的瘦型大鼠中更能增加食物摄入量。孕酮在两组中对食物摄入量的增加作用相似。对皮质酮反应性增强可能是肥胖型大鼠许多代谢缺陷的原因。
