Frame J W, Browne R M, Brady C L
Biomaterials. 1981 Jan;2(1):19-22. doi: 10.1016/0142-9612(81)90082-x.
Densely sintered calcium hydroxyapatite has previously been shown to be biocompatible and stable. Its possible role in jaw surgery was investigated using a clinically analogous animal model. The apatite was implanted into the mandible of twelve dogs for 12 weeks, and the healing assessed radiologically and histologically. The new bone which was deposited directly onto the surface of the implants bonded them firmly to the adjacent tissues. There was no fibrous tissue between implant and bone. This material appears to be a suitable substitute for autogenous bone when used as inert 'space filler' in maxillo-facial surgical procedures.
高密度烧结羟基磷灰石先前已被证明具有生物相容性且性质稳定。利用临床类似的动物模型研究了其在颌骨手术中的潜在作用。将磷灰石植入12只狗的下颌骨中12周，并通过放射学和组织学评估愈合情况。直接沉积在植入物表面的新骨将它们牢固地与相邻组织结合在一起。植入物与骨之间没有纤维组织。当用作颌面外科手术中的惰性“空间填充材料”时，这种材料似乎是自体骨的合适替代品。
