Kato K, Aoki H, Tabata T, Ogiso M
Biomater Med Devices Artif Organs. 1979;7(2):291-7. doi: 10.3109/10731197909117584.
Apatite ceramics composed of synthetic hydroxyapatite, Ca10(PO4)6(OH)2 were implanted in mandibles of adults dogs. The histological observations indicated that the apatite ceramic was closely contacted with newly formed bone tissue without any rejection phenomenon up to 2 weeks. An electron micrograph of non-decalcified ultra-thin section at 8 weeks showed that the apatite ceramic was directly bonded to newly formed bone and the mineralized bone tissue was grown into the micro pores of the ceramics independent on the pore size. It seemed that the outer surface of the apatite was exchanged by bone tissue. From these results it was considered that the apatite ceramic was a successful implant material in dental and surgical fields.
将由合成羟基磷灰石Ca10(PO4)6(OH)2组成的磷灰石陶瓷植入成年犬的下颌骨。组织学观察表明，直至2周时，磷灰石陶瓷与新形成的骨组织紧密接触，无任何排斥现象。8周时非脱钙超薄切片的电子显微照片显示，磷灰石陶瓷与新形成的骨直接结合，矿化的骨组织长入陶瓷的微孔中，与孔径无关。似乎磷灰石的外表面被骨组织所替代。从这些结果可以认为，磷灰石陶瓷是牙科和外科领域一种成功的植入材料。
