Department of Materials Science and Metallurgy, University of Cambridge, New Museum's Site, Pembroke Street, Cambridge CB2 3QZ, UK.
J Mater Sci Mater Med. 2012 Oct;23(10):2335-47. doi: 10.1007/s10856-012-4598-2. Epub 2012 Mar 3.
Calcium phosphates such as hydroxyapatite have a wide range of applications both in bone grafts and for the coating of metallic implants, largely as a result of their chemical similarity to the mineral component of bone. However, to more accurately mirror the chemistry, various substitutions, both cationic (substituting for the calcium) and anionic (substituting for the phosphate or hydroxyl groups) have been produced. Significant research has been carried out in the field of substituted apatites and this paper aims to summarise some of the key effect of substitutions including magnesium, zinc, strontium, silicon and carbonate on physical and biological characteristics. Even small substitutions have been shown to have very significant effects on thermal stability, solubility, osteoclastic and osteoblastic response in vitro and degradation and bone regeneration in vivo.
钙磷酸盐，如羟磷灰石，在骨移植物和金属植入物的涂层中有广泛的应用，这主要是因为它们在化学上与骨的矿物质成分相似。然而，为了更准确地反映化学性质，已经产生了各种取代物，包括阳离子（取代钙）和阴离子（取代磷酸盐或羟基）。在取代磷灰石领域进行了大量的研究，本文旨在总结取代物（包括镁、锌、锶、硅和碳酸盐）对物理和生物特性的一些关键影响。即使是小的取代也已被证明对热稳定性、溶解度、体外破骨细胞和成骨细胞反应以及体内降解和骨再生有非常显著的影响。
