Guyton A C, Hall J E, Lohmeier T E, Jackson T E, Kastner P R
Fed Proc. 1981 Jun;40(8):2252-6.
In this paper we have attempted to explain the difference between proportional pressure control systems and the renal-blood volume-pressure control mechanism, which is an infinite gain pressure control system. Because of this infinite gain of the kidney mechanism, this mechanism has the capability of returning arterial pressure all the way back to the control leve. Furthermore, this mechanism can override the other pressure control mechanisms because of its extreme control capability. On the other hand, the renal-blood volume mechanism for pressure control itself be controlled by many other factors. These other factors are said to change the pressure "set-point" level of the renal system, and then the renal system automatically brings the pressure to the set-point level. It is especially noteworthy, however, that some of the factors that play extreme roles in short-term pressure control-such as heart strength, vascular capacity, and total peripheral resistance-will not alter the long-term arterial pressure level (unless they in some way concurrently alter the set-point of the kidney mechanism).
在本文中，我们试图解释比例压力控制系统与肾血流量 - 压力控制机制之间的差异，肾血流量 - 压力控制机制是一种具有无限增益的压力控制系统。由于肾脏机制的这种无限增益，该机制有能力将动脉血压一直恢复到控制水平。此外，由于其极强的控制能力，该机制能够超越其他压力控制机制。另一方面，用于压力控制的肾血流量机制本身会受到许多其他因素的控制。据说这些其他因素会改变肾系统的压力“设定点”水平，然后肾系统会自动将压力调节到设定点水平。然而，特别值得注意的是，一些在短期压力控制中起关键作用的因素，如心脏强度、血管容量和总外周阻力，不会改变长期动脉血压水平（除非它们以某种方式同时改变肾脏机制的设定点）。
