Schusdziarra V, Dangel G, Klier M, Henrichs I, Pfeiffer E F
J Clin Endocrinol Metab. 1981 Jul;53(1):16-20. doi: 10.1210/jcem-53-1-16.
The present study was designed to determine the effect of sucrose-containing liquids upon postprandial pancreatic endocrine function in comparison to an identical quantity of sucrose contained in the solid part of the test meal. In 10 normal subjects, the ingestion of a solid-liquid meal with sucrose in the liquid part elicited a significantly greater increase in the plasma insulin and glucose levels during the first 20 min than did the ingestion of the same meal in homogenized form. Plasma glucagon levels fell below baseline during the early phase of the meal in response to the solid-liquid meal, whereas values increased immediately upon ingestion of the homogenized meal. To determine the effect of repeated ingestion of sucrose-containing liquids, 6 subjects ingested a meal containing sucrose in solid form together with water (solid sucrose); on another occasion, the same subjects ingested the sucrose in liquid form. In response to the liquid-sucrose meal, mean postprandial plasma insulin levels were significantly higher than those observed in response to the solid-sucrose meal (110 +/- 11.3 vs. 80 +/- 8.5 microunits/ml; P less than 0.01) as were plasma glucagon levels (284 +/- 12.2 vs. 198 +/- 8.2 pg/ml; P less than 0.001). Mean postprandial plasma glucose levels and the insulin to glucagon ratio were not different. The present data demonstrate that the ingestion of sucrose in the liquid part of a meal results in a significant elevation of plasma insulin concentrations compared to the ingestion of sucrose in the solid part of the meal.
本研究旨在确定含蔗糖液体对餐后胰腺内分泌功能的影响，并与试验餐固体部分中相同量的蔗糖进行比较。在10名正常受试者中，摄入液体部分含蔗糖的固体 - 液体餐，在前20分钟内血浆胰岛素和葡萄糖水平的升高幅度明显大于摄入均质形式的同一餐。在进食固体 - 液体餐的早期阶段，血浆胰高血糖素水平降至基线以下，而摄入均质餐时该值立即升高。为了确定重复摄入含蔗糖液体的影响，6名受试者摄入了含有固体形式蔗糖的餐食并同时饮水（固体蔗糖）；在另一次试验中，相同受试者摄入液体形式的蔗糖。对液体蔗糖餐的反应中，餐后血浆胰岛素平均水平显著高于对固体蔗糖餐的反应（110±11.3对80±8.5微单位/毫升；P<0.01），血浆胰高血糖素水平也是如此（284±12.2对198±8.2皮克/毫升；P<0.001）。餐后血浆葡萄糖平均水平和胰岛素与胰高血糖素比值没有差异。目前的数据表明，与餐食固体部分摄入蔗糖相比，餐食液体部分摄入蔗糖会导致血浆胰岛素浓度显著升高。
