Troy J L, Silvers D N, Grossman M E, Jaffe I A
J Am Acad Dermatol. 1981 May;4(5):547-55. doi: 10.1016/s0190-9622(81)70055-0.
Penicillamine-associated bullous eruptions share with spontaneously occurring pemphigus intraepidermal acantholysis, epidermal intercellular deposition of immunoglobulin, and circulating serum antibody against the intercellular regions of the epidermis. We report the case of a penicillamine-associated bullous eruption in which there were some of the histologic features of pemphigus, but none of the immunofluorescent features. Instead, the immunofluorescent findings of bullous pemphigoid were demonstrated. Review of the literature reveals that clinical and histologic features of penicillamine-associated bullous eruptions differ in important respects from those of spontaneously occurring pemphigus. Our report adds immunologic data to evidence that the penicillamine-associated bullous eruptions may not be the same disease as spontaneously occurring pemphigus.
青霉胺相关的大疱性皮疹与自发性天疱疮一样，具有表皮内棘层松解、免疫球蛋白在表皮细胞间沉积以及循环血清中存在针对表皮细胞间区域的抗体等特征。我们报告了一例青霉胺相关的大疱性皮疹病例，该病例具有一些天疱疮的组织学特征，但无免疫荧光特征。相反，显示出了大疱性类天疱疮的免疫荧光表现。文献回顾表明，青霉胺相关的大疱性皮疹的临床和组织学特征在重要方面与自发性天疱疮不同。我们的报告补充了免疫学数据，以证明青霉胺相关的大疱性皮疹可能与自发性天疱疮不是同一种疾病。
