Korngold R, Bennink J R, Doherty P C
J Immunol. 1981 Jul;127(1):124-9.
The number of cells in the thymus of [k leads to (b X k)F1] radiation (100 rad) chimeras increases approximately 10-fold between 7 and 14 days after reconstitution with bone marrow. At least 50% of the cells in thymus on day 14 are of host origin and respond to virus presented in the context of both H-2k and H-2b when primed in irradiated, virus-infected (b X k)F1 recipients. Strong CTL responses can be generated from thymocytes of donor origin on day 21. All evidence of a significant host thymocyte component has disappeared by day 28. The responsiveness of 14-day thymocytes is not abrogated by pretreatment of the mice used to make the chimeras with anti-thymocyte serum or by using doses of irradiation as high as 1200 rads to eliminate host components.
用骨髓重建后7至14天内，[k导致(b×k)F1]辐射（100拉德）嵌合体小鼠胸腺中的细胞数量增加约10倍。在第14天，胸腺中至少50%的细胞来源于宿主，当在受辐照的、感染病毒的(b×k)F1受体中致敏时，这些细胞对在H-2k和H-2b背景下呈递的病毒产生反应。在第21天，可从供体来源的胸腺细胞产生强烈的细胞毒性T淋巴细胞（CTL）反应。到第28天，宿主胸腺细胞显著成分的所有证据均消失。用抗胸腺细胞血清预处理用于制备嵌合体的小鼠，或使用高达1200拉德的辐照剂量来消除宿主成分，均不会消除14天龄胸腺细胞的反应性。
