Bach J F
J Mal Vasc. 1980;5(4):307-14.
The clinical manifestations of necrotizing angeiitis are of many types (periarteritis nodosa, Wegener's granulomatosis, hypersensitivity, vasculitis...). Their immunological origin is strongly suggested by their analogy with the experimental models of immune complex diseases, and the presence of many immunological anomalies indicating the presence and intervention of these complexes. Several arguments strongly suggest that immunological factors may be also implicated in the pathogenesis of arterial hypertension and arteriosclerosis.
坏死性血管炎的临床表现有多种类型(结节性多动脉炎、韦格纳肉芽肿病、超敏性血管炎……)。它们与免疫复合物疾病的实验模型相似,且存在许多表明这些复合物存在及作用的免疫异常现象,强烈提示其免疫起源。有多个论据有力地表明,免疫因素可能也与动脉高血压和动脉硬化的发病机制有关。