Galler M, Folkert V W, Schlondorff D
JAMA. 1981 Jul 10;246(2):154-5.
We noted five cases of reversible acute deterioration of renal function in patients with very mild to moderate renal insufficiency who received indomethacin for an acute gouty attack. This decrease in renal function was consistent with a primary decrease in renal blood flow. In addition, hyperkalemia developed in the patients, which we attribute to a decrease in renin and aldosterone secretion, a decrease in distal tubular delivery of sodium, and, more importantly, to a decrease in urine flow. This report is intended to alert physicians to the possible complications of indomethacin therapy in patients with mild renal insufficiency.
我们注意到，在患有非常轻度至中度肾功能不全的患者中，有5例因急性痛风发作接受吲哚美辛治疗后出现可逆性急性肾功能恶化。这种肾功能下降与肾血流量的原发性减少一致。此外，患者出现了高钾血症，我们将其归因于肾素和醛固酮分泌减少、远端肾小管钠输送减少，更重要的是，归因于尿流量减少。本报告旨在提醒医生注意吲哚美辛治疗对轻度肾功能不全患者可能产生的并发症。
