[乙酰水杨酸愈创木酚酯对慢性阻塞性支气管肺炎患者肺量计和体积描记参数的影响]
[Effects of guaiacolic ester of acetylsalicylic acid on spirometric and plethysmographic parameters in subjects with chronic obstructive bronchopneumopathy].
作者信息
Bonaduce D, Postiglione M, Ferrara N, Petretta M, De Caprio L, Rengo F
出版信息
Minerva Med. 1981 Feb 28;72(7):333-7.
The effects of oral administration of guaiacolic ester of acetyl salicilic acid in 24 patients with chronic obstructive lung disease have been evaluated. 1.5 g of this drug were given daily into 3 administrations improving both objective and subjective symptomatology in 19 of the 24 patients after 1 or 3 weeks of treatment. Moreover, a statistically significant improvement of FEV 1" (p less than 0.001), Raw (p less than 0.005) and FEV 1"/VC (p less than 0.01) was observed. The remaining 5 patients discontinued the treatment failing the improvement of the subjective symptomatology.
已评估口服乙酰水杨酸愈创木酯对24例慢性阻塞性肺疾病患者的疗效。每日给予该药物1.5克，分3次服用，治疗1周或3周后，24例患者中有19例的客观和主观症状均得到改善。此外，观察到第1秒用力呼气量（FEV₁）（p<0.001）、气道阻力（Raw）（p<0.005）和FEV₁/肺活量（VC）（p<0.01）有统计学意义的改善。其余5例患者因主观症状未改善而停止治疗。
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