Cerqua R, Trovello C, Infante G, Ricciardi S
Minerva Med. 1981 Feb 28;72(7):355-62.
A single-blind, between-patients trial was run to compare the fluidifying, expectorant, antitussive, antipyretic and anti-inflammatory activity, and the local and systemic tolerance of guacetisal, an active principle obtained by the esterification of acetylsalicylic acid and guaiacol, and oxolamine phosphate, in which the suspension formulation for adults was administered to 30 presenile and senile patients of both sexes with chronic obstructive bronchopathy. A higher activity on the part of guacetisal was noted. The results obtained are illustrated and discussed.
进行了一项单盲、患者间试验,以比较乙酰水杨酸与愈创木酚酯化得到的活性成分瓜西沙星和磷酸奥索胺的流化、祛痰、镇咳、解热和抗炎活性,以及局部和全身耐受性。将成人混悬液制剂给予30例患有慢性阻塞性支气管病的老年前期和老年男女患者。结果显示瓜西沙星的活性更高。对所得结果进行了说明和讨论。