免疫抑制治疗的结果是否受免疫遗传标志物的影响？
Are results of immunosuppressive therapy influenced by immunogenetic markers?
作者信息
Sasinka M, Nyulassy S, Dzúrik R, Buc M, Slugen I, Pavlovic M, Stefanovic J, Menkyna R
出版信息
Proc Eur Dial Transplant Assoc. 1980;17:608-11.
A group of 157 children, 4-15 years old, suffering from various forms of glomerulonephritis were investigated. Associations between the HLA system and the clinical, morphological and therapeutic responses were looked for. The study revealed the following associations: chronic GN to B15 and B18; Schönlein-Henoch GN to B27, Bw35 and Bw40; focal GN to B18; mesangioproliferative GN to B27; susceptibility to corticosteroids to B18; resistance to corticosteroids to B15.
对一组157名4至15岁患有各种形式肾小球肾炎的儿童进行了调查。研究了HLA系统与临床、形态学及治疗反应之间的关联。该研究揭示了以下关联：慢性肾小球肾炎与B15和B18相关；过敏性紫癜性肾小球肾炎与B27、Bw35和Bw40相关；局灶性肾小球肾炎与B18相关；系膜增生性肾小球肾炎与B27相关；对皮质类固醇敏感与B18相关；对皮质类固醇耐药与B15相关。
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