蛋白质结合型甲硫氨酸亚砜的酶促还原作用。
Enzymatic reduction of protein-bound methionine sulfoxide.
作者信息
Brot N, Weissbach L, Werth J, Weissbach H
出版信息
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2155-8. doi: 10.1073/pnas.78.4.2155.
Abstract
An enzyme that catalyzes the reduction of methionine sulfoxide residues in ribosomal protein L12 has been partially purified from Escherichia coli extracts. Methionine sulfoxide present in oxidize [Met]enkephalin is also reduced by the purified enzyme. The enzyme is different from a previously reported E. coli enzyme that catalyzes the reduction of methionine sulfoxide to methionine [Ejiri, S. I., Weissbach, H. & Brot, N. (1980) Anal. Biochem. 102, 393--398]. Extracts of rat tissues, Euglena gracilis, Tetrahymena pyriformis, HeLa cells, and spinach also can catalyze the reduction of methionine sulfoxide residues in protein.
摘要
一种催化核糖体蛋白L12中甲硫氨酸亚砜残基还原的酶已从大肠杆菌提取物中部分纯化出来。氧化型脑啡肽中存在的甲硫氨酸亚砜也能被纯化后的该酶还原。该酶不同于先前报道的一种大肠杆菌酶，后者催化甲硫氨酸亚砜还原为甲硫氨酸[Ejiri, S. I., Weissbach, H. & Brot, N. (1980) Anal. Biochem. 102, 393 - 398]。大鼠组织、纤细裸藻、梨形四膜虫、海拉细胞和菠菜的提取物也能催化蛋白质中甲硫氨酸亚砜残基的还原。
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