Reitamo S, Konttinen Y T, Dodd S, Adinolfi M
Acta Paediatr Scand. 1981;70(3):395-8. doi: 10.1111/j.1651-2227.1981.tb16570.x.
We used an immunoperoxidase method to study the distribution of lactoferrin in seven human fetuses from 11 to 21 weeks of age. Lactoferrin was found in mononuclear cells, presumably granulocytes, in various organs from thirteen weeks of gestation onwards. In addition to the liver, spleen, lung and thymus, lactoferrin-positive mononuclear cells were also found close to vessel walls in human pancreas in fetuses more than 20 weeks old. This finding might suggest that there is significant granulopoiesis in the pancreas at this stage of maturation. In addition to the mononuclear cells, lactoferrin could be found in Hassal's corpuscles of the thymus from 13 weeks and in glandular cells of the tongue from 20 weeks onwards. The present results are in good agreement with the maturation of humoral and cellular acquired immunity and the onset of synthesis of lysozyme and interferon.
我们采用免疫过氧化物酶法研究了7例11至21周龄人类胎儿中乳铁蛋白的分布情况。从妊娠13周起，在各器官的单核细胞（可能是粒细胞）中发现了乳铁蛋白。除肝脏、脾脏、肺和胸腺外，在20周以上胎儿的人类胰腺中，靠近血管壁处也发现了乳铁蛋白阳性单核细胞。这一发现可能表明，在这个成熟阶段胰腺中有显著的粒细胞生成。除单核细胞外，从13周起在胸腺的哈氏小体中以及从20周起在舌的腺细胞中均可发现乳铁蛋白。目前的结果与体液免疫和细胞获得性免疫的成熟以及溶菌酶和干扰素合成的开始高度一致。
