Kazachkina N I, Kokhanova I D, Egorova S E, Nemtsova E R, Pugachev K K
Arkh Anat Gistol Embriol. 1988 May;94(5):19-23.
By means of the indirect immunoperoxidase method in deparaffinized slices a comparative investigation on distribution of the female milk lactoferrin (LF) in tissues of the mature person and in the fetus has been performed. LF is revealed in cells of the neutrophil line of the mature person and of the fetus and in the secretory epithelium of some organs of the mature person (in the mammary, submandibular and parotid salivary glands, in the bronchial mucous membrane glands in the fundal and pyloric glands of the stomach). In all the cases investigated LF is revealed in the cells producing serous secrete: in the cells of the serous terminal parts and in the serous semilunar mixed terminal parts of the salivary glands, in the serous cells of the bronchial glands and in the chief cells of the gastric mucous membrane glands. In the fetal secretory epithelium of the organs LF is not found. As LF is revealed in the secretory epithelium of the mature person and is not revealed in the corresponding epithelium of the fetus, it should be considered as a marker of the cells, that reach certain degree of differentiation.
采用间接免疫过氧化物酶法，对石蜡切片中成熟个体和胎儿组织中女性乳腺乳铁蛋白（LF）的分布进行了比较研究。在成熟个体和胎儿的中性粒细胞系细胞以及成熟个体某些器官的分泌上皮中发现了LF（在乳腺、下颌下腺和腮腺、支气管黏膜腺、胃底腺和幽门腺中）。在所有研究的病例中，LF在产生浆液性分泌物的细胞中被发现：在唾液腺的浆液性终末部分细胞和浆液性半月形混合终末部分细胞中、支气管腺的浆液性细胞中以及胃黏膜腺的主细胞中。在胎儿器官的分泌上皮中未发现LF。由于在成熟个体的分泌上皮中发现了LF，而在胎儿相应上皮中未发现，因此应将其视为达到一定分化程度的细胞的标志物。
