Taylor A N, Branch B J, Liu S H, Wiechmann A F, Hill M A, Kokka N
Alcohol Clin Exp Res. 1981 Spring;5(2):237-46. doi: 10.1111/j.1530-0277.1981.tb04895.x.
Long lasting effects of perinatal ethanol exposure were studied in adult rats who were the offspring of dams fed a 5.0% w/v ethanol-containing liquid diet ad libitum or pair-fed the isocaloric control diet during gestation weeks 2 and 3 or during postnatal week 1. Fetal exposure to ethanol reduced body weight of pups at birth unless the ethanol diet was supplemented with casein; neonatal exposure to the ethanol or pair-fed diets, casein supplemented or not, reduced pup weights until day 21 postnatally when weights of all fetally or neonatally exposed pups were normal. Between 52 and 120 days of age females were tested for pituitary-adrenal and temperature responses to a challenge dose of ethanol. Prenatally ethanol-exposed rats showed significantly higher plasma corticosterone titers and developed a greater hypothermia in response to an intraperitoneal injection of ethanol (0.75--1.5 g/kg) than did pair-fed controls. Similar responses enhancement did not occur in the postnatally ethanol-exposed rats. Temporal patterns of blood ethanol levels after an intraperitoneal injection of ethanol (1.5 g/kg) were similar in prenatally ethanol-exposed females and their pair-fed controls. The data indicate that exposure to ethanol in utero exerts persistent effects on the offspring, rendering them more responsive to the hypothermic and pituitary-adrenal activating effects of alcohol as adults.
研究了围产期乙醇暴露对成年大鼠的长期影响，这些成年大鼠是母鼠的后代，母鼠在妊娠第2和第3周或出生后第1周随意喂食含5.0%（w/v）乙醇的液体饮食或等量喂食等热量对照饮食。胎儿期暴露于乙醇会降低幼崽出生时的体重，除非乙醇饮食中补充了酪蛋白；新生儿期暴露于乙醇或等量喂食的饮食中，无论是否补充酪蛋白，都会降低幼崽体重，直到出生后第21天，此时所有胎儿期或新生儿期暴露的幼崽体重均正常。在52至120日龄期间，对雌性大鼠进行垂体-肾上腺和体温对乙醇挑战剂量的反应测试。与等量喂食的对照组相比，产前暴露于乙醇的大鼠在腹腔注射乙醇（0.75 - 1.5 g/kg）后，血浆皮质酮滴度显著升高，体温降低幅度更大。产后暴露于乙醇的大鼠未出现类似的反应增强。产前暴露于乙醇的雌性大鼠及其等量喂食的对照组在腹腔注射乙醇（1.5 g/kg）后血液乙醇水平的时间模式相似。数据表明，子宫内暴露于乙醇会对后代产生持续影响，使它们成年后对酒精的体温降低和垂体-肾上腺激活作用更敏感。
