氨苯砜治疗类风湿关节炎对比安慰剂的双盲试验。
Double-blind trial of dapsone against placebo in the treatment of rheumatoid arthritis.
作者信息
Swinson D R, Zlosnick J, Jackson L
出版信息
Ann Rheum Dis. 1981 Jun;40(3):235-9. doi: 10.1136/ard.40.3.235.
Abstract
Dapsone given over 14 weeks in a dose of 50 mg a day for 1 week and thereafter 100 mg a day was found to have a beneficial effect in rheumatoid arthritis when compared with placebo administration to a matched group of patients. Significant improvement in 5 out of 7 clinical measurements and in erythrocyte sedimentation rate, viscosity, C-reactive protein was found in those patients taking dapsone. There was significant improvement compared to the placebo group in 2 out of the 7 clinical measurements and again in all 3 acute-phase reactants. The drug was quite well tolerated over the 14-week duration of the trial. The tendency to cause haemolysis will be its main limiting factor as a practical alternative to other suppressive agents currently in use.
摘要
与给予匹配患者组安慰剂相比，发现氨苯砜以每日50毫克的剂量服用1周，之后每日100毫克，持续14周，对类风湿性关节炎有有益效果。服用氨苯砜的患者在7项临床测量中的5项以及红细胞沉降率、粘度、C反应蛋白方面有显著改善。与安慰剂组相比，在7项临床测量中的2项以及所有3种急性期反应物方面均有显著改善。在14周的试验期间，该药物耐受性良好。导致溶血的倾向将是其作为目前使用的其他抑制药物的实际替代药物的主要限制因素。
相似文献
1
Double-blind trial of dapsone against placebo in the treatment of rheumatoid arthritis.氨苯砜治疗类风湿关节炎对比安慰剂的双盲试验。
Ann Rheum Dis. 1981 Jun;40(3):235-9. doi: 10.1136/ard.40.3.235.
2
A double-blind comparative study of hydroxychloroquine and dapsone, alone and in combination, in rheumatoid arthritis.羟氯喹和氨苯砜单独及联合使用治疗类风湿性关节炎的双盲对比研究。
Scand J Rheumatol. 1993;22(3):113-8. doi: 10.3109/03009749309099254.
3
[Treatment of rheumatoid polyarthritis with dapsone. A controlled study versus placebo].[氨苯砜治疗类风湿性多关节炎。与安慰剂对照的研究]
Rev Rhum Mal Osteoartic. 1989 Mar 15;56(4):313-6.
4
[Treatment of rheumatoid arthritis with dapsone].[用氨苯砜治疗类风湿性关节炎]
Ugeskr Laeger. 1983 Sep 12;145(37):2847-8.
5
Dapsone in rheumatoid arthritis.氨苯砜治疗类风湿关节炎
Semin Arthritis Rheum. 1996 Jun;25(6):390-403. doi: 10.1016/s0049-0172(96)80004-7.
6
Report on chloroquine and dapsone in the treatment of rheumatoid arthritis: a 6-month comparative study.氯喹和氨苯砜治疗类风湿性关节炎的报告：一项为期6个月的对照研究。
Ann Rheum Dis. 1984 Apr;43(2):200-4. doi: 10.1136/ard.43.2.200.
7
Dapsone in rheumatoid arthritis.氨苯砜治疗类风湿关节炎
Rheumatol Rehabil. 1976 Aug;15(3):230-4. doi: 10.1093/rheumatology/15.3.230.
8
Effects of gold, dapsone, and prednisone on serum C-reactive protein and haptoglobin and the erythrocyte sedimentation rate in rheumatoid arthritis.金、氨苯砜和泼尼松对类风湿关节炎患者血清C反应蛋白、触珠蛋白及红细胞沉降率的影响
Ann Rheum Dis. 1979 Apr;38(2):141-4. doi: 10.1136/ard.38.2.141.
9
[Dapsone in the treatment of rheumatoid polyarthritis. Double-blind study (11 cases) and open study (7 cases)].[氨苯砜治疗类风湿性多关节炎。双盲研究（11例）和开放研究（7例）]
Rev Rhum Mal Osteoartic. 1985 Oct;52(10):587-9.
10
Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group.米诺环素治疗类风湿性关节炎。一项为期48周的双盲、安慰剂对照试验。MIRA试验组。
Ann Intern Med. 1995 Jan 15;122(2):81-9. doi: 10.7326/0003-4819-122-2-199501150-00001.
引用本文的文献
1
Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms.慢性疼痛的抗菌治疗（第1部分）：镇痛机制。
Korean J Pain. 2023 Jul 1;36(3):281-298. doi: 10.3344/kjp.23129.
2
Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation.支持胶质母细胞瘤放化疗期间采用节拍式氨苯砜的初步研究。
Med Sci (Basel). 2021 Feb 16;9(1):12. doi: 10.3390/medsci9010012.
3
Dapsone in rheumatoid arthritis.氨苯砜治疗类风湿关节炎
Ann Rheum Dis. 1981 Dec;40(6):630. doi: 10.1136/ard.40.6.630-a.
4
Report on chloroquine and dapsone in the treatment of rheumatoid arthritis: a 6-month comparative study.氯喹和氨苯砜治疗类风湿性关节炎的报告：一项为期6个月的对照研究。
Ann Rheum Dis. 1984 Apr;43(2):200-4. doi: 10.1136/ard.43.2.200.
5
Outcome of attempts to treat rheumatoid arthritis with gold, penicillamine, sulphasalazine, or dapsone.使用金制剂、青霉胺、柳氮磺胺吡啶或氨苯砜治疗类风湿性关节炎的尝试结果。
Ann Rheum Dis. 1984 Jun;43(3):398-401. doi: 10.1136/ard.43.3.398.
6
Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial.青霉胺与柳氮磺胺吡啶治疗类风湿性关节炎的比较：利兹-伯明翰试验。
Br Med J (Clin Res Ed). 1983 Oct 15;287(6399):1099-102. doi: 10.1136/bmj.287.6399.1099.
7
Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.氨苯砜被人肝微粒体酶生物激活为细胞毒性代谢物。
Br J Clin Pharmacol. 1989 Oct;28(4):389-95. doi: 10.1111/j.1365-2125.1989.tb03517.x.
本文引用的文献
1
Agranulocytosis due to dapsone.氨苯砜所致粒细胞缺乏症
Ann Intern Med. 1970 Apr;72(4):521-4. doi: 10.7326/0003-4819-72-4-521.
2
Malabsorption in rheumatoid disease.类风湿性疾病中的吸收不良。
Ann Rheum Dis. 1971 Nov;30(6):626-30. doi: 10.1136/ard.30.6.626.
3
4
Inhibition of lysosomal enzymes by dapsone.
Arch Dermatol. 1974 Oct;110(4):563-6.
5
Dapsone in rheumatoid arthritis.氨苯砜治疗类风湿关节炎
Rheumatol Rehabil. 1976 Aug;15(3):230-4. doi: 10.1093/rheumatology/15.3.230.
6
Leprosy and the rheumatoid factor.麻风病与类风湿因子。
Cent Afr J Med. 1978 Jan;24(1):8-10.
7
Levamisole in rheumatoid arthritis--a multivariate analysis of a multicentric study.类风湿关节炎中的左旋咪唑——一项多中心研究的多变量分析
J Rheumatol Suppl. 1978;4:17-25.
8
Effects of gold, dapsone, and prednisone on serum C-reactive protein and haptoglobin and the erythrocyte sedimentation rate in rheumatoid arthritis.金、氨苯砜和泼尼松对类风湿关节炎患者血清C反应蛋白、触珠蛋白及红细胞沉降率的影响
Ann Rheum Dis. 1979 Apr;38(2):141-4. doi: 10.1136/ard.38.2.141.
9
Evidence for prevention of borderline leprosy reactions by dapsone.氨苯砜预防界线类麻风反应的证据。
Lancet. 1976 Nov 27;2(7996):1171-2. doi: 10.1016/s0140-6736(76)91684-6.
10
Letter: Coeliac disease and autoimmunity.信件：乳糜泻与自身免疫
Lancet. 1976 May 1;1(7966):964. doi: 10.1016/s0140-6736(76)92742-2.
Zotero 插件