Lewi P J, Symoens J
J Rheumatol Suppl. 1978;4:17-25.
Statistical analysis of the data from a multicentric study of six months of treatment with levamisole in rheumatoid arthritis involved two steps. In a first step, the differences between observations before and after treatment have been made independent of their initial values. Differences after treatment have been transformed into responses to treatment using a proportionality factor that is related to the initial values before treatment. The second step involved a reduction of the various responses into a single global response by means of a discriminant analysis between two classes. Class membership has been defined by the type of treatment (either placebo or drug) predicted by the investigators at the end of treatment and before breaking of the code of the double-blind study. This method of analysis allows for the combination of multiple clinical observations with a subjective evaluation. Its results can be easily represented graphically and tested for statistical significance. The use of global responses to treatment is illustrated with a comparison of placebo and drug treatments and can be extended to comparisons between investigators or between different dose and time regimens.
对类风湿性关节炎患者使用左旋咪唑进行为期六个月的多中心研究的数据进行统计分析包括两个步骤。第一步，治疗前后观察值之间的差异已与它们的初始值无关。治疗后的差异已通过与治疗前初始值相关的比例因子转化为对治疗的反应。第二步涉及通过两类之间的判别分析将各种反应简化为单一的总体反应。类别归属已根据研究人员在治疗结束时和双盲研究代码破解之前预测的治疗类型（安慰剂或药物）来定义。这种分析方法允许将多个临床观察结果与主观评估相结合。其结果可以很容易地用图形表示并进行统计学显著性检验。通过安慰剂和药物治疗的比较说明了对治疗总体反应的使用，并且可以扩展到研究人员之间或不同剂量和时间方案之间的比较。
