Yabe Y, Yasui M, Yoshino N, Fujiwara T, Ohkuma N, Nohara N
J Invest Dermatol. 1978 Oct;71(4):225-8. doi: 10.1111/1523-1747.ep12515089.
Two cases of epidermodysplasia verruciformis were studied histologically and electron microscopically. Four lesions examined were histologically benign, and had viral particles morphologically similar to that of common human warts. Two lesions on the forehead and the face were histologically in the stages of malignant transformation, the intraepidermal epithelioma and the early invasive squamous cell carcinoma. Similar viral particles were also observed in the upper layers of these 2 lesions. These results suggest that at least some of the virus-induced lesions of epidermodysplasia verruciformis actually become malignant.
对两例疣状表皮发育不良患者进行了组织学和电子显微镜检查。所检查的四个损害在组织学上为良性，且具有形态学上与寻常疣相似的病毒颗粒。前额和面部的两个损害在组织学上处于恶性转化阶段，即表皮内上皮瘤和早期浸润性鳞状细胞癌。在这两个损害的上层也观察到了类似的病毒颗粒。这些结果表明，疣状表皮发育不良中至少一些由病毒引起的损害实际上会发生恶变。
