Caputo R, Innocenti M, Gasparini G, Peluchetti D
J Invest Dermatol. 1978 Oct;71(4):245-9. doi: 10.1111/1523-1747.ep12515095.
A freeze-fracture study of affected and unaffected psoriatic skin has demonstrated the presence of marked modification of the plasma membrane in the psoriatic lesion. In the lower layers of the epidermis, an increase of membrane associated particles was observed in many keratinocytes, possibly representing the morphological intramembranous equivalent of changes in the outer cell membrane demonstrated with cytochemical techniques. Furthermore, in the malphighian layer, numerous gap junctions have been found, which may be interpreted as a phenomenon compensating the uncontrolled proliferation, and may represent a point of differentiation between cell proliferation in psoriasis and neoplasia. This technique confirmed the poor tendency to adhesion of keratinocytes in extrajunctional areas, which had already been shown by other morphological techniques.
一项对患银屑病皮肤和未患银屑病皮肤的冷冻断裂研究表明，银屑病皮损处的质膜存在明显改变。在表皮下层，许多角质形成细胞中观察到膜相关颗粒增加，这可能代表了细胞化学技术所显示的外细胞膜变化在形态学上的膜内对应物。此外，在马尔皮基层发现了大量缝隙连接，这可能被解释为一种补偿不受控制的增殖的现象，并且可能代表银屑病中细胞增殖与肿瘤形成之间的一个分化点。这项技术证实了连接外区域角质形成细胞黏附性差的倾向，这一点已被其他形态学技术所证实。
