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[围产期猪血浆中胰岛素和皮质醇水平及肾上腺质量]

[Insulin and cortisol levels in blood plasma and adrenal gland mass in swine during the perinatal period].

作者信息

Brenner K V, Gürtler H, Müller I, Grün E

出版信息

Arch Exp Veterinarmed. 1981;35(2):211-21.

PMID:7018446
Abstract

The level of immunoreactive insulin activity and glucose in blood plasma of the umbilical vein was found to be lower than that in maternal venous blood plasma, in the last third of intra-uterine development, that is between the 80th and 112th day. No age-dependent differences were recordable regarding immunoreactive insulin activity in foetal blood plasma. Concentrations of glucose and immunoreactive insulin in venous blood plasma of piglets were found to rise, within 24 hours from birth, due to milk intake. Such rises were statistically significant but differed by individuals. None of the above parameters increased in fasting piglets. Cortisol in foetal blood plasma was found to be low, usually less than 5 ng/ml, on the 80th, 100th, and 106th day of intra-uterine life, but it went up between the 106th and 112th day. The highest concentrations were recorded from the oldest foetuses, 114 day of intra-uterine development. The cortisol levels in the blood plasma of the mothers of the above mentioned foetuses varied between 5 ng/ml and 70 ng/ml. Relative adrenal gland weight in animals aged 112 and 114 days was found to be significantly higher than that in foetuses aged 80, 100, and 106 days. No significant postnatal change in relative adrenal gland weight was recorded from piglets in the first nine days of life.

摘要

在子宫内发育的最后三分之一阶段,即第80至112天期间,发现脐静脉血浆中的免疫反应性胰岛素活性和葡萄糖水平低于母体静脉血浆中的水平。关于胎儿血浆中的免疫反应性胰岛素活性,未记录到年龄依赖性差异。发现仔猪静脉血浆中的葡萄糖和免疫反应性胰岛素浓度在出生后24小时内由于摄入乳汁而升高。这种升高具有统计学意义,但个体之间存在差异。禁食仔猪的上述参数均未增加。在子宫内生活的第80、100和106天,胎儿血浆中的皮质醇水平较低,通常低于5 ng/ml,但在第106至112天之间有所上升。最高浓度记录于最老的胎儿,即子宫内发育114天的胎儿。上述胎儿母亲血浆中的皮质醇水平在5 ng/ml至70 ng/ml之间变化。发现112和114日龄动物的相对肾上腺重量显著高于80、100和106日龄胎儿的相对肾上腺重量。在出生后的头九天内,未记录到仔猪相对肾上腺重量的显著产后变化。

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