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[骨髓移植中的细胞遗传学。I. 骨髓再生障碍]

[Cytogenetics in bone marrow transplantations. I. Bone marrow aplasia].

作者信息

Palka G, Jovine R, D'Antuono A, Caramelli E, Bonora B, Di Marzio S, Bartoli S

出版信息

Boll Soc Ital Biol Sper. 1981 Jan 15;57(1):20-6.

PMID:7018519
Abstract

A bone marrow transplantation has been carried out in a patient with bone marrow aplasia. Besides the cytochemical and haematological tests, the cytogenetic analysis has been performed to check whether the transplantation was successful. In this case the donor was the patient's sister, so that the presence of the chimere has been used as a criteria for judging the conditions of the transplantation. the cytogenetic analysis, furthermore, is suitable to detect other chromosome abnormalities, which can represent a condition of instability of the transplanted cells and are probably an early expression of the transplanted bone marrow.

摘要

已对一名骨髓再生障碍患者进行了骨髓移植。除了细胞化学和血液学检查外,还进行了细胞遗传学分析,以检查移植是否成功。在这种情况下,供体是患者的姐姐,因此嵌合体的存在已被用作判断移植情况的标准。此外,细胞遗传学分析适用于检测其他染色体异常,这些异常可能代表移植细胞的不稳定状态,并且可能是移植骨髓的早期表现。

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