Sarles H, Laugier R
Clin Gastroenterol. 1981 May;10(2):401-15.
Although further work is needed for understanding the mechanism of the action of alcohol on the pancreas, it can be admitted that in man, the rat and the dog, chronic alcohol consumption leads to precipitation of proteins in the juice and the ducts. When these precipitates are observed, an alteration of the protein to bicarbonate ratio is always found, as a result of an increase in protein concentration or a decrease in bicarbonate concentration, or both, It is reasonable to assume that an increased cholinergic tone is responsible for the increased secretion of protein. The decrease in bicarbonate secretion is not explained. It is worthwhile mentioning that, in hypercalcaemic dogs, protein precipitates are found in the juice associated with an increased concentration of protein and a decreased concentration of bicarbonate. It is known that hypercalcaemia (hyperparathyroidism) is a cause of chronic calcifying pancreatitis (noel-Jorand et al, 1981b).
尽管还需要进一步开展工作来了解酒精对胰腺的作用机制，但可以承认，在人类、大鼠和狗身上，长期饮酒会导致胰液和导管中蛋白质沉淀。当观察到这些沉淀物时，由于蛋白质浓度增加或碳酸氢盐浓度降低，或两者兼而有之，总是会发现蛋白质与碳酸氢盐的比例发生改变。有理由认为胆碱能张力增加是蛋白质分泌增加的原因。碳酸氢盐分泌减少的原因尚不清楚。值得一提的是，在高钙血症犬中，在胰液中发现了蛋白质沉淀，同时蛋白质浓度增加而碳酸氢盐浓度降低。众所周知，高钙血症（甲状旁腺功能亢进）是慢性钙化性胰腺炎的一个病因（诺埃尔 - 若兰德等人，1981b）。
