Sarles H, Tiscornia O, Sahel J
Leber Magen Darm. 1976 Aug;6(4):206-9.
The earliest change during chronic pancreatitis seems to be precipitation of proteic material consisting apparently of the normal components of pancreatic juice, as demonstrated by pathology studies. Similar changes could be induced in animal experiments. There seems to be a causal relationship between increased protein concentration in pancreatic juice and protein precipitation. The cause of the disease in most cases is alcoholism combined with a diet rich in fat and proteins, or malnutrition in infants. The mechanism of action was clarified in dogs and rats: An increase of cholinergic stimulation influencing pancreatic secretion directly seems to be involved as well as an indirect stimulation of pancreatic secretion by gastroduodenal hormones.
病理研究表明，慢性胰腺炎最早的变化似乎是蛋白质物质的沉淀，这些蛋白质物质显然由胰液的正常成分组成。在动物实验中也能诱发类似的变化。胰液中蛋白质浓度增加与蛋白质沉淀之间似乎存在因果关系。在大多数情况下，该病的病因是酗酒，再加上富含脂肪和蛋白质的饮食，或婴儿营养不良。在狗和大鼠身上阐明了其作用机制：直接影响胰腺分泌的胆碱能刺激增加似乎参与其中，以及胃肠激素对胰腺分泌的间接刺激。
