Jacobsen G K, Rygaard J, Povlsen C O
Exp Cell Biol. 1981;49(3):148-53. doi: 10.1159/000163817.
Two different malignant tumours were transplanted prior to or after thymus grafts in nude mice, and the degree of immunological reconstitution was studied. All mice which rejected either of the tumour types had reconstitution as expressed by an excess of splenic plaque-forming cells. The level of response was dependent upon the age of the thymus graft and whether a tumour was transplanted or not. In contrast, the result of the phytohaemagglutinin stimulation assays of spleen cells were always subnormal in thymus-grafted as well as in thymus- plus tumour-transplanted mice.
在裸鼠的胸腺移植之前或之后移植两种不同的恶性肿瘤，并研究免疫重建的程度。所有排斥任何一种肿瘤类型的小鼠都有免疫重建，表现为脾斑形成细胞过量。反应水平取决于胸腺移植的年龄以及是否移植了肿瘤。相比之下，在移植了胸腺的小鼠以及移植了胸腺和肿瘤的小鼠中，脾细胞的植物血凝素刺激试验结果总是低于正常水平。
