Jacobsen G K, Povlsen C O, Rygaard J
Exp Cell Biol. 1979;47(6):409-29. doi: 10.1159/000162960.
The effect of neonatal thymus grafts implanted in nude mice previously transplanted with three different human malignant tumors - an adenocarcinoma of the colon, a malignant melanoma and a Burkitt's lymphoma - were studied. In all immunologically reconstituted animals tumord were rejected. Tumor rejection stated 2-3 weeks after thymus implantation, and was completed after 30-6 weeks. Histological examination of lymphoid tissues showed a correlation between immunological reconstitution and tumor rejection. The rejection process showed a characteristic histologic picture with 3 phases - an early, an intermediate and a late phase - these were similar in the three tumor types examined. The possible mechanisms of reconstitution and tumor rejection are discussed.
研究了将新生胸腺移植到先前移植了三种不同人类恶性肿瘤（结肠腺癌、恶性黑色素瘤和伯基特淋巴瘤）的裸鼠体内的效果。在所有免疫重建的动物中，肿瘤均被排斥。肿瘤排斥反应在胸腺植入后2至3周开始，30至6周后完成。对淋巴组织的组织学检查显示免疫重建与肿瘤排斥之间存在相关性。排斥过程呈现出具有三个阶段（早期、中期和晚期）的特征性组织学图像，在所检查的三种肿瘤类型中这些阶段相似。文中讨论了重建和肿瘤排斥的可能机制。
