Weiser M M, Andres G A, Brentjens J R, Evans J T, Reichlin M
Gastroenterology. 1981 Sep;81(3):570-9.
A 22-yr-old woman with a 7-yr history of systemic lupus erythematosus presented with anasarca and a serum albumin of 0.8 g/dl. Renal and hepatic function were near normal; the major route of protein loss appeared to be the intestine. A full-thickness section of jejunum obtained at laparotomy demonstrated a severe, diffuse vasculitis involving the venules of the submucosa and muscularis externa with infiltration of polymorphonuclear leukocytes and macrophages, and deposits of C3. There was a similar focal damage of the walls of the small vessels in the lamina propria, and deposits of C3 and fibrinogen in a thickened basement membrane of the intestinal villi. This report documents that in systemic lupus erythematosus the intestine can be affected with a vasculitis similar to that seen in the skin and can cause thickening of the basement membrane of intestinal villi. These lesions may be responsible for protein-losing enteropathy.
一名患有系统性红斑狼疮7年的22岁女性出现全身水肿，血清白蛋白为0.8g/dl。肾功能和肝功能接近正常；蛋白质丢失的主要途径似乎是肠道。剖腹手术时获取的一段空肠全层切片显示，严重的弥漫性血管炎累及黏膜下层和外肌层的小静脉，有中性粒细胞和巨噬细胞浸润以及C3沉积。固有层小血管壁有类似的局灶性损伤，肠绒毛增厚的基底膜中有C3和纤维蛋白原沉积。本报告证明，在系统性红斑狼疮中，肠道可受到类似于皮肤所见的血管炎影响，并可导致肠绒毛基底膜增厚。这些病变可能是蛋白丢失性肠病的原因。
